Anesthesia Management: Anesthesia Risk Outside of OR
Author : Doc Clemens
Here is an excellent article from the Journal of Anesthesia Safety Foundation
The demand for anesthesia care for procedures performed outside the operating room (out-of-OR) has dramatically increased in recent years. Advances in diagnostic and interventional procedures, constraints on operating room time and costs, and the desire of patients for sedation and lack of recall, all contribute to the increase in popularity of anesthesia in remote locations. The delivery of safe anesthesia care may be difficult in out-of-OR settings due to a variety of challenges, including cramped, dark rooms, inadequate anesthesia support, unfamiliar environment, and variability of monitoring modalities. Although the majority of procedures in remote locations are relatively non-invasive, serious adverse outcomes can occur.
ASA Closed Claims Project Review
Because of these safety hazards, we analyzed claims for injuries from 1990 and later in the American Society of Anesthesiologists (ASA) Closed Claims database to compare injuries associated with claims for anesthesia care in remote locations (n=87) with anesthesia injuries in the operating room setting (n=3286).1 The ASA Closed Claims Project is a structured evaluation of adverse anesthesia events obtained from closed malpractice claim files from professional liability insurance companies throughout the United States.2 Claims for dental damage are excluded.
Patients in remote locations were older (20% greater than 70 years of age), sicker (69% ASA 3-5), and more often underwent an emergent procedure (36%) than patients in operating room claims.1 The predominant anesthetic technique in remote location claims was monitored anesthesia care (MAC), which was 8-times more frequent than in operating room claims (50% vs. 6 %).1 The facilities most commonly involved were the gastrointestinal (GI) suite (32% of the remote location claims) and cardiology catheterization/electrophysiology laboratories (25% of remote location claims). Other locations included the emergency room, lithotripsy suites, and radiology, especially the magnetic resonance imaging (MRI) scanner. The severity of patient injury was greater in remote location claims than in operating room claims, with the proportion of death almost double in the remote location claims. In contrast, operating room claims were more often associated with temporary injuries, such as transient nerve injuries.1 Although the most common mechanism of injury in both remote location and operating room claims was an adverse respiratory event, the proportion of respiratory events in remote locations was double that in the operating rooms. Inadequate oxygenation/ventilation was the most common respiratory-related adverse event in remote location claims, occurring 7 times more frequently than in operating room claims. The injuries in remote locations were more often judged as being preventable by better monitoring.
Respiratory depression due to an absolute or relative overdose of sedative-hypnotic-analgesic drugs was responsible for 26 remote location claims, accounting for more than half of the claims in the GI suite. Other oversedation claims also occurred in radiology (MRI scanner), the lithotripsy unit, and cardiology laboratories. Patient factors for oversedation were obesity, sleep apnea, ASA status 3-5, and age greater than 70 years.
Propofol was the most common drug used, either as a single agent or in combination with other drugs. Notably, a capnograph was employed in only a minority of claims associated with oversedation (15%) and no respiratory monitoring was used in 15% of these claims. Substandard care, preventable by better monitoring, was implicated in the majority of claims associated with death.
Monitoring for Respiratory Events
In a report of 153 deaths occurring in the GI suite without the presence of anesthesia personnel, only half were monitored by pulse oximeter, and none by capnography.3 A pulse oximeter monitors oxygen saturation, not ventilation, which is accomplished by a precordial or esophageal stethoscope, capnography, or electrical impedance monitoring. Detection of apnea or hypoventilation by pulse oximetry alone may be delayed in patients receiving supplemental oxygen.4 Apnea lasting 20s or more is common in patients undergoing MAC and is not easily detected by clinical signs or pulse oximetry without the use of capnography or electrical impedance monitoring.5,6 Capnography alerts practitioners to respiratory depression and apnea before hypoxemia develops, especially if supplemental oxygen is used. The ASA recently revised its standards of anesthesia monitoring to include use of capnography during monitored anesthesia care, particularly during upper endoscopy procedures. While capnography is useful in all patients undergoing sedation and MAC, it is especially important for sedation of patients with probable or known obstructive sleep apnea. In such a case, strong consideration should be given to securing the airway with general endotracheal anesthesia (instead of deep sedation) for procedures with poor access to the airway, such as those in the prone position, MRI scanner, or lithotripsy unit, due to the difficulty of immediate airway control and cardiopulmonary resuscitation.
In summary, data from the ASA Closed Claims Project demonstrates that MAC in remote locations poses a significant risk for oversedation and inadequate oxygenation/ventilation due to delays in recognition of respiratory depression. Knowledge of the pharmacokinetic properties of sedative/analgesic drugs, careful monitoring of respiration including capnography, and vigilance can minimize the risk of patient injury in these challenging settings. In addition, general anesthesia with endotracheal intubation may be safer than deep sedation in some patients (e.g., obstructive sleep apnea) and procedures (e.g., prone position, MRI scanner, poor access to patient’s airway).